How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation?

• Main Author: Antoine Toubert (auth)
• Other Authors: Hermann Einsele (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; cell therapy; Immune reconstitution; Haplo-SCT; HSCT; Thymic function
• Online Access: DOAB: download the publication; DOAB: description of the publication

Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent...