Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins

• Päätekijä: Giovanni Blandino (auth)
• Muut tekijät: Ygal Haupt (auth)
• Aineistotyyppi: Elektroninen Kirjan osa
• Kieli: englanti
• Julkaistu: Frontiers Media SA 2016
• Sarja: Frontiers Research Topics
• Aiheet: Medicine; mouse models; mutant p53; dominant netagive; therapies; Oncogenic addiction; gain of function
• Linkit: DOAB: download the publication; DOAB: description of the publication

TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to t...