Human Tumor-Derived p53 Mutants: A Growing Family of Oncoproteins

• Main Author: Giovanni Blandino (auth)
• Other Authors: Ygal Haupt (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2016
• Series: Frontiers Research Topics
• Subjects: Medicine; mouse models; mutant p53; dominant netagive; therapies; Oncogenic addiction; gain of function
• Online Access: DOAB: download the publication; DOAB: description of the publication

TP53 gene mutations are present in more than half of all human cancers. The resulting proteins are mostly full-length with a single amino acid change and are abundantly expressed in cancer cells. Some of the mutant p53 proteins gain oncogenic functions (GOF) through which it actively contribute to t...