Immune responses to AAV vectors, from bench to bedside

• Main Author: Hildegard Buning (auth)
• Other Authors: Federico Mingozzi (auth), Etiena Basner Tschakarjan (auth), Anne Galy (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; antibody response; Clinical Trial; Gene Therapy; Regulatory T Cell; Immunomodulation; Tolerance induction; adaptive and innate immunity; adeno-associated virus; Vaccine; Epitopes
• Online Access: DOAB: download the publication; DOAB: description of the publication

The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, aden...