Inhibiting PARP as a Strategic Target in Cancer

• Yazar: Kristin Zorn (auth)
• Diğer Yazarlar: Christina Annunziata (auth)
• Materyal Türü: Elektronik Kitap Bölümü
• Dil: İngilizce
• Baskı/Yayın Bilgisi: Frontiers Media SA 2016
• Seri Bilgileri: Frontiers Research Topics
• Konular: Medicine; DNA reapir; PARP inhibitor; Homologous Recombination; combination therapy; DNA Damage; Cancer
• Online Erişim: DOAB: download the publication; DOAB: description of the publication

Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell's ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types...