Inhibiting PARP as a Strategic Target in Cancer

• Main Author: Kristin Zorn (auth)
• Other Authors: Christina Annunziata (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2016
• Series: Frontiers Research Topics
• Subjects: Medicine; DNA reapir; PARP inhibitor; Homologous Recombination; combination therapy; DNA Damage; Cancer
• Online Access: DOAB: download the publication; DOAB: description of the publication

Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell's ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types...