Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges

• मुख्य लेखक: Gabazza, Esteban C. (auth)
• स्वरूप: इलेक्ट्रोनिक पुस्तक अध्याय
• भाषा: अंग्रेज़ी
• प्रकाशित: MDPI - Multidisciplinary Digital Publishing Institute 2019
• विषय: Medicine; bleomycin; n/a; regeneration; antitumor efficacy; lung cancer; SOX2; leiomyosarcoma; lung cancer (LC); nanoparticles; cytokines; hepatocellular carcinoma; metabolic reprogramming; hepatic stellate cells; angiogenesis; transforming growth factor-?; anaplastic lymphoma kinase; idiopathic pulmonary fibrosis; growth factor; pathogenesis; cancer-associated fibroblasts; fibrosis; lipopolysaccharide; DHA; lncRNA; SREBP-1; YAP; protein S; non-small cell lung cancer (NSCLC); omega-3 fatty acid; inflammation; metastasis; clinical symptoms; miRNA; smooth muscle tumor of uncertain malignant potential; Wnt; interstitial fluid pressure; heterogeneity; hepatocytes; myometrium; tumor necrosis factor ?; tumor; tumor microenvironment; extracellular matrix; TAZ; carcinogenesis; cystic formation; pulmonary fibrosis; HBV; cytokine; genetic instability; diagnosis; EMT; crizotinib; Hippo pathway; GPR120; marker; HCV; non-alcoholic steatohepatitis; pathology; common pathways; apoptosis; type I collagen; GPR40; acute lung injury; uterine fibroid; renal injury; pathophysiology; reactive oxygen species; immunohistochemistry; SMAD; butylidenephthalide; leiomyoma; cirrhosis; Erk1/2; targeted therapy; TGF-?; mechanotransduction; therapy; breast cancer; hepatocellular carcinoma (HCC); hepatic stellate cells (HSCs); idiopathic pulmonary fibrosis (IPF); cancer-associated fibroblasts (CAFs); cancer; signal pathway; tumor stiffness
• ऑनलाइन पहुंच: DOAB: download the publication; DOAB: description of the publication

Tissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases, autoimmune disorders, graft rejection, or malignancy. On the other hand, malignant tumors have been identified in fibrotic tissues decades ago, an...