Links between Fibrogenesis and Cancer: Mechanistic and Therapeutic Challenges: Mechanistic and Therapeutic Challenges

• Main Author: Gabazza, Esteban C. (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Medicine; bleomycin; n/a; regeneration; antitumor efficacy; lung cancer; SOX2; leiomyosarcoma; lung cancer (LC); nanoparticles; cytokines; hepatocellular carcinoma; metabolic reprogramming; hepatic stellate cells; angiogenesis; transforming growth factor-?; anaplastic lymphoma kinase; idiopathic pulmonary fibrosis; growth factor; pathogenesis; cancer-associated fibroblasts; fibrosis; lipopolysaccharide; DHA; lncRNA; SREBP-1; YAP; protein S; non-small cell lung cancer (NSCLC); omega-3 fatty acid; inflammation; metastasis; clinical symptoms; miRNA; smooth muscle tumor of uncertain malignant potential; Wnt; interstitial fluid pressure; heterogeneity; hepatocytes; myometrium; tumor necrosis factor ?; tumor; tumor microenvironment; extracellular matrix; TAZ; carcinogenesis; cystic formation; pulmonary fibrosis; HBV; cytokine; genetic instability; diagnosis; EMT; crizotinib; Hippo pathway; GPR120; marker; HCV; non-alcoholic steatohepatitis; pathology; common pathways; apoptosis; type I collagen; GPR40; acute lung injury; uterine fibroid; renal injury; pathophysiology; reactive oxygen species; immunohistochemistry; SMAD; butylidenephthalide; leiomyoma; cirrhosis; Erk1/2; targeted therapy; TGF-?; mechanotransduction; therapy; breast cancer; hepatocellular carcinoma (HCC); hepatic stellate cells (HSCs); idiopathic pulmonary fibrosis (IPF); cancer-associated fibroblasts (CAFs); cancer; signal pathway; tumor stiffness
• Online Access: DOAB: download the publication; DOAB: description of the publication

Tissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases, autoimmune disorders, graft rejection, or malignancy. On the other hand, malignant tumors have been identified in fibrotic tissues decades ago, an...