Macromolecular Structure Underlying Recognition in Innate Immunity

• Main Author: Uttara SenGupta (auth)
• Other Authors: Maha Ahmed Al-Mozaini (auth), Uday Kishore (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2018
• Series: Frontiers Research Topics
• Subjects: Medicine; HIV-1; host-pathogen interactions; zebrafish model system; innate immunity; protein-protein interaction; complement; malaria; pattern recognition
• Online Access: DOAB: download the publication; DOAB: description of the publication

Immune molecules have evolved to distinguish "self "molecules from "non-self", "altered self" and "danger" molecules. Recognition is mediated via interactions between pattern recognition receptor molecules (PPRs) and their ligands, which include hydrophobic an...