Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions

• Main Author: Lluis Fajas (auth)
• Other Authors: Albert Giralt (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2018
• Series: Frontiers Research Topics
• Subjects: Medicine; cancer metabolism; proliferation; mitochondria; lipogenesis; metabolic adaptation; obesity; Warburg effect
• Online Access: DOAB: download the publication; DOAB: description of the publication

Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent...