Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions

• Hoofdauteur: Lluis Fajas (auth)
• Andere auteurs: Albert Giralt (auth)
• Formaat: Elektronisch Hoofdstuk
• Taal: Engels
• Gepubliceerd in: Frontiers Media SA 2018
• Reeks: Frontiers Research Topics
• Onderwerpen: Medicine; cancer metabolism; proliferation; mitochondria; lipogenesis; metabolic adaptation; obesity; Warburg effect
• Online toegang: DOAB: download the publication; DOAB: description of the publication

Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent...