Metabolic Adaptation to Cell Growth and Proliferation in Normal and Pathological Conditions

• المؤلف الرئيسي: Lluis Fajas (auth)
• مؤلفون آخرون: Albert Giralt (auth)
• التنسيق: الكتروني فصل الكتاب
• اللغة: الإنجليزية
• منشور في: Frontiers Media SA 2018
• سلاسل: Frontiers Research Topics
• الموضوعات: Medicine; cancer metabolism; proliferation; mitochondria; lipogenesis; metabolic adaptation; obesity; Warburg effect
• الوصول للمادة أونلاين: DOAB: download the publication; DOAB: description of the publication

الملخص

Proliferating cells must adapt their metabolism to fulfill the increased requirements for energy demands and biosynthetic intermediates. This adaptation is particularly relevant in cancer, where sustained rapid proliferation combined with the harsh conditions of the tumor microenvironment represent a major metabolic challenge. Noteworthy, metabolic reprogramming is now considered one of the hallmarks of cancer. However, the one size fits all rarely applies to the metabolic rewiring occurring in cancer cells, which ultimately depends on the combination of several factors such as the tumor's origin, the specific genetic alterations and the surrounding microenvironment. In the present Research Topic, we compile a series of articles that discuss different metabolic adaptations that proliferating cells undergo to sustain growth and division, as well as the potential therapeutic window to treat certain pathologies, with a special focus on cancer.

وصف مادي

1 electronic resource (70 p.)

ردمك

978-2-88945-484-6
9782889454846

وصول

Open Access