The metabolic challenges of immune cells in health and disease

• Main Author: Christian Frezza (auth)
• Other Authors: Claudio Mauro (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; metabolic syndrome; Obesity; Immunometabolism; TCA cycle; Glycolysis; macrophage; Inflammation; fatty acid oxidation; Pentose Phosphate Pathway; lymphocyte
• Online Access: DOAB: download the publication; DOAB: description of the publication

Obesity and its co-morbidities, including atherosclerosis, insulin resistance and diabetes, are a world-wide epidemic. Inflammatory immune responses in metabolic tissues have emerged as a universal feature of these metabolic disorders. While initial work highlighted the contribution of macrophages t...