The Metabolic-Inflammatory Axis in Brain Aging and Neurodegeneration

• Main Author: Enrique Cadenas (auth)
• Other Authors: Jia Yao (auth), Fei Yin (auth), Roberta Diaz Brinton (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Neurosciences; Brain aging; Mitochondria; Energy Metabolism; neurodegeneration; Neuroinflammation; Perimenopause; redox homeostasis; Alzheimer's disease; diabetes
• Online Access: DOAB: download the publication; DOAB: description of the publication

Impairment of energy metabolism is a hallmark of brain aging and several neurodegenerative diseases, such as the Alzheimer's disease (AD). Age- and disease-related hypometabolism is commonly associated with oxidative stress and they are both regarded as major contributors to the decline in syna...