Metals and neurodegeneration: Restoring the balance

• Main Author: Katja M. Kanninen (auth)
• Other Authors: Anthony R. White (auth), Peter J. Crouch (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2016
• Series: Frontiers Research Topics
• Subjects: Neurosciences; Brain; neurodegenerative disease; Neurons; Metals; Iron; Copper; Alzheimer's disease; Zinc; Manganese
• Online Access: DOAB: download the publication; DOAB: description of the publication

Biometals such as copper, zinc and iron have key biological functions, however, aberrant metabolism can lead to detrimental effects on cell function and survival. These biometals have important roles in the brain, driving cellular respiration, antioxidant activity, intracellular signaling and many a...