Microglial Polarization in the Pathogenesis and Therapeutics of Neurodegenerative Diseases

• 1. Verfasser: Isidre Ferrer (auth)
• Weitere Verfasser: Yu Tang (auth)
• Format: Elektronisch Buchkapitel
• Sprache: Englisch
• Veröffentlicht: Frontiers Media SA 2018
• Schriftenreihe: Frontiers Research Topics
• Schlagworte: Neurosciences; M2 Microglia; Microglial Polarization; Neurodegenerative diseases; M1 Microglia; Aging; Neuroinflammation; M1/M2 Switch
• Online-Zugang: DOAB: download the publication; DOAB: description of the publication

Microglia-mediated neuroinflammation is one of the shared prominent hallmarks among various forms of neurodegeneration. Depending on the milieu in which microglia become activated, the polarization of microglia shows to be heterogeneous with diverse functional phenotypes that range from pro-inflamma...