Model-Based Tools for Pharmaceutical Manufacturing Processes

• Main Author: Gernaey, Krist V. (auth)
• Other Authors: Schenkendorf, Rene (auth), Gerogiorgis, Dimitrios I. (auth), Mansouri, Seyed Soheil (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; n/a; sensitivity analysis; parametric probability-box; non-isothermal modelling; dynamic optimisation; batch-to-batch variation; pharmaceutical manufacturing; process kinetics; flowsheet modeling; continuous manufacturing; MATLAB Production Server; flexibility analysis; polynomial chaos; probabilistic design space; bypassing; ODE model; enzymatic reaction; enzymatic synthesis; parameter estimation; freeze-drying; reversible reaction; diffusion of innovation; multi-objective decision-making; software development; continuous stirred tank reactor; parenteral manufacturing; wet granulation; spectroscopic assay; process design; dynamic modelling; quality by design; Fourier analysis; residence time distribution; point estimate method; model integration; global optimization; robust process design; pharmaceutical processes; return on investment; Amoxicillin; pyrimidine-nucleoside phosphorylase; spray drying; single-use technology; global sensitivity analysis; process modeling
• Online Access: DOAB: download the publication; DOAB: description of the publication

The Special Issue on "Model-Based Tools for Pharmaceutical Manufacturing Processes" will curate novel advances in the development and application of model-based tools to address ever-present challenges of the traditional pharmaceutical manufacturing practice as well as new trends. This boo...