Molecular Basis of Cardiovascular Diseases: Implications of Natriuretic Peptides

• Main Author: Rubattu, Speranza (auth)
• Other Authors: Volpe, Massimo (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Medicine; postmortem biochemistry; medulla; animal models; remodeling; BNP; PCSK9; guanylyl cyclase/natriuretic peptide receptor-A; cardiorenal syndrome; forensic medicine; preserved ejection fraction; kidney; renin-angiotensin-aldosterone system; atrial fibrillation; vasopressor; congestive heart failure; atrial natriuretic peptide; gene-knockout; obesity; heart failure; angiogenesis; adipose tissue; vascular; LDL receptor; metabolic syndrome; linkage analysis; cardiometabolic disease; cardiomyocyte; cardiac dysfunction; cardiac hypertrophy; insulin; lipid metabolism; cGMP; Idiopathic Pulmonary Arterial Hypertension (IPAH); Natriuretic Peptide Clearance Receptor (NPR-C) signaling; gene-duplication; renin-angiotensin system; natriuretic peptides; angiotensin receptor-neprilysin inhibitor; cardiac remodelling; ARNi; NT-proBNP; inflammation; pulmonary arterial hypertension; vascular homeostasis; endothelial cell; Atrial Natriuretic peptide; natriuretic peptide; vasodilator; stroke; genetic variants; arterial hypertension; fibroblast; MANP; hypertension; guanylyl cyclase receptor A
• Online Access: DOAB: download the publication; DOAB: description of the publication

The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.