Molecular Chaperones and Neurodegeneration

• Main Author: Cintia Roodveldt (auth)
• Other Authors: Janice E. Braun (auth), Tiago F. Outeiro (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Neurosciences; molecular chaperone; therapeutics; neurodegenerative disease; heat-shock response; protein misfolding; neuroprotection; neurodegeneration; heat-shock protein; proteostasis; amyloid protein
• Online Access: DOAB: download the publication; DOAB: description of the publication

Molecular chaperones or heat-shock proteins (HSPs) play essential roles in safeguarding structural stability and preventing misfolding and aggregation of proteins, and maintaining the proteome functionality in the cell. For over two decades until the present time, new functions have been discovered...