Molecular Mechanism of Alzheimer's Disease

• Main Author: Macreadie, Ian (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Biology, life sciences; HOTAIR; neurosciences; sleep disturbance; positron emission tomography (PET); vitamin B complex; neurodegeneration; Tau; miR-15/107; default-mode network; complement receptor 1; neuronal differentiation; epigenetics; brain glucose metabolism; oligomerization; genetic risk; A?O receptors; prion; ryanodine receptor; type 3 diabetes; complement; cognitive behavioral therapy for insomnia; cognitive function; epigenome-wide association study; Alzheimer's disease; calcium signaling; ?-secretase; tau; Prolyl isomerases; NEAT1; complement C3b/C4b receptor; proteostasis; amyloid beta; yeast; slow-wave sleep; amyloid ?; nutrition; 4; protein aggregation; apolipoprotein E; dementia; MALAT1; inositol 1; lncRNAs; molecular biology; methylenetetrahydrofolate reductase MTHFR gene; 5-trisphosphate receptor; CR1 density; miR-34c; aggregation; heat shock protein; dendritic spine; S-adenosylmethionine; beta amyloid; ion channel; inflammation; sleep fragmentation; cystathionine-?-lyase CTH gene; DNA methylation; heat shock response; microglia; drug target discovery; amyloid-? oligomer; therapy; CR1 length polymorphism; methylome; APOE gene; ubiquitin; magnetic resonance imaging (MRI); neuronal degeneration; type 2 diabetes; Pin1; mild cognitive impairment; dairy products; endoplasmic reticulum; oxidative stress; Hispanics; CDK5R1
• Online Access: DOAB: download the publication; DOAB: description of the publication

Alzheimer's disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of stud...