Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications

• मुख्य लेखक: Megan Chircop (auth)
• अन्य लेखक: Daniel Speidel (auth)
• स्वरूप: इलेक्ट्रोनिक पुस्तक अध्याय
• भाषा: अंग्रेज़ी
• प्रकाशित: Frontiers Media SA 2015
• श्रृंखला: Frontiers Research Topics
• विषय: Medicine; DNA Repair; DNA Damage; tumorigenesis; therapeutic targets; chemotherapy; Apoptosis; cellular stress; therapy resistance
• ऑनलाइन पहुंच: DOAB: download the publication; DOAB: description of the publication

In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or...