Molecular mechanisms of cellular stress responses in cancer and their therapeutic implications

• Main Author: Megan Chircop (auth)
• Other Authors: Daniel Speidel (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; DNA Repair; DNA Damage; tumorigenesis; therapeutic targets; chemotherapy; Apoptosis; cellular stress; therapy resistance
• Online Access: DOAB: download the publication; DOAB: description of the publication

In response to stress, cells can activate a myriad of signalling pathways to bring about a specific cellular outcome, including cell cycle arrest, DNA repair, senescence and apoptosis. This response is pivotal for tumour suppression as all of these outcomes result in restriction of the growth and/or...