mTOR in Human Diseases

• Main Author: Dormond, Olivier (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Medicine; n/a; primary cilia; neurodegeneration; nutrient sensor; PI3K; transcriptomics; phosphorylation; metabolic reprogramming; autophagy; Alzheimer's disease; rapalogs; liver; angiogenesis; mTOR complex; MBSCs; advanced biliary tract cancers; Medulloblastoma; epithelial to mesenchymal transition; AMPK; p70S6K; lipid metabolism; thyroid cancer; sodium iodide symporter (NIS)/SLC5A5; male fertility; anesthesia; illumina; mTOR inhibitor; miRNA; Hutchinson-Gilford progeria syndrome (HGPS); eIFs; Emery-Dreifuss muscular dystrophy (EDMD); glucose; AKT; oral cavity squamous cell carcinoma (OSCC); glucose and lipid metabolism; cellular signaling; aging; tumor microenvironment; rapamycin; leukemia; chloral hydrate; rapalogues; schizophrenia; T-cell acute lymphoblastic leukemia; senescence; lamin A/C; neurotoxicity; neurodevelopment; inhibitor; methamphetamine; pulmonary fibrosis; mTOR; mTOR inhibitors; combination therapy; proteolysis; fluid shear stress; tumour cachexia; biomarkers; synapse; gluconeogenesis; mTOR signal pathway; Sertoli cells; immunosenescence; miRNome; protein aggregation; senolytics; metabolism; NGS; mTORC2; mTORC1; metabolic diseases; IonTorrent; apoptosis; dopamine receptor; nocodazole; microenvironment; everolimus; acute myeloid leukemia; immunotherapy; spermatogenesis; bone remodeling; signalling; targeted therapy; ageing; therapy; NVP-BEZ235; fructose; physical activity; laminopathies; MC3T3-E1 cells; cell signaling; microRNA; cancer; lipolysis; melatonin; Parkinson's disease
• Online Access: DOAB: download the publication; DOAB: description of the publication

The mechanistic target of rapamycin (mTOR) is a major signaling intermediary that coordinates favorable environmental conditions with cell growth. Indeed, as part of two functionally distinct protein complexes, named mTORC1 and mTORC2, mTOR regulates a variety of cellular processes, including protei...