Multidrug resistance in Cancer: Pharmacological Strategies from Basic Research to Clinical Issues

• Main Author: Chiara Riganti (auth)
• Other Authors: Enrico Mini (auth), Stefania Nobili (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; multidrug resistance; reversing strategies; P-Glycoprotein; Cancer
• Online Access: DOAB: download the publication; DOAB: description of the publication

More than 40 years ago, the observation that doxorubicin-resistant tumor cells were cross-resistant to several structurally different anticancer agents was the first step in the discovery of P-glycoprotein (P-gp). P-gp belongs to the superfamily of ATP-binding cassette (ABC) transporters;its overexp...