Mysteries of Type I IFN response: benefits versus detriments

• Main Author: Herbert Patrick Ludewick (auth)
• Other Authors: Arno Mullbacher (auth), Yoichi Furuya (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; Autoimmunity; adjuvant; bacterial and viral infections; Vaccine; type I IFN
• Online Access: DOAB: download the publication; DOAB: description of the publication

Successful containment of an infection is dependent on both innate and adaptive immune response. Cytokines are essential effectors of both of these systems. In particular, type I interferons (IFN-I) are important components of early innate immunity against an infection. However, the production of IF...