Natural Products and Drug Discovery

• Hoofdauteur: Avato, Pinarosa (auth)
• Formaat: Elektronisch Hoofdstuk
• Taal: Engels
• Gepubliceerd in: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Onderwerpen: Biology, life sciences; dihydrochalcones; cytotoxicity-guided; n/a; harpagoside; biotechnology; synergy; Imperata cylindrica; 5?-dimethylchalcone (DMC); antioxidant activity; marine resources; phenolic derivatives; secondary metabolites; antimicrobial agents; antimicrobial resistance; metabolomics; Humulus lupulus; chromatography; stereochemistry; FSE; cytokines; cytotoxic activity; glutamate; angiogenesis; traditional medicine; Ca2+; L6 cell; human colon cancer cell lines; siphonous green algae; anti-inflammatory activity; Phyllanthus chamacristoides; spectroscopic analysis; Physcomitrella patens; Leishmania mexicana mexicana; dementia; prenylated phenolic compounds; T2DM; HPLC-ESI-microTOF-Q-MS/MS; Eruca sativa; Dryopteris fragrans; chemosystematics; 2?; cerebellum; Cleistocalyx operculatus; inflammation; multivariate data analysis; Phyllanthus orbicularis; HPLC; cardiovascular disease; Kv7 potassium channels; marine peptides; proliferation; sulfated coumarins; Orobanche s.l.; phenylpropanoid glycosides; Harpagophytum procumbens; sesquiterpenoids; TRPV1; Fideloside; phenylethanoid glycosides; Cuba; molecular network; NMR; ketamine; aging; GLUT4; diabetes; oxidative stress; Lamiales; circular dichroism; psychosis; antinociceptive; immuno-regulation activity; terpenoids; NADPH oxidases; diabetic neuropathy; spagyric tincture; H2S; celastrol; isolation and quantification; 4?-dihydroxy-6?-methoxy-3?; Leea indica; C-glycoside; neuropathic pain; PANC-1; glucosinolates; flavonoids; bioactivities of natural products; cardamonin; isoflavones; terpenes; methicillin-resistant Staphylococcus aureus; malaria; artemisinin; natural products; devil's claw; ACE inhibitory peptide; pPancreatic cancer; growth inhibitory activity; mass spectrometry; flavonoid; phenolics; Astragalus boeticus L.; proanthocyanidins; opioid; Trifolium; Trypanosoma brucei brucei; acetylated astragalosides; Fabaceae; bioactive peptides; LC-MS; Dasycladus vermicularis; Orobanchaceae; migration; glucoerucin; ESI-MS/MS; cancer; zebrafish; antihypertensive; Bacopa monnieri; chemical derivatization; hypertension
• Online toegang: DOAB: download the publication; DOAB: description of the publication

Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terr...