Neuropeptide GPCRs in Neuroendocrinology

• Main Author: Jae Young Seong (auth)
• Other Authors: Hubert Vaudry (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2014
• Series: Frontiers Research Topics
• Subjects: Transduction pathways; G protein-coupled receptors; Neuroendocrinology; Heptahelical receptors; Neuropeptides; Signaling mechanisms; Biologically active peptides; seven-transmembrane domain receptors
• Online Access: DOAB: download the publication; DOAB: description of the publication

The human genome encompasses ~ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrin...