Novel Pharmacological Inhibitors for Bacterial Protein Toxins

• Main Author: Holger Barth (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2017
• Subjects: Biology, life sciences; Bacterial AB-toxins; infection; Shiga toxin; semicarbazone EGA; pore-forming toxins; Botulinum Neurotoxin (BoNT); black lipid bilayer membrane; cellular uptake; intracellular transport; anthrax toxins; Clostridium perfringens toxins; Diphtheria toxin; Clostridium difficile toxins; pore-blockers; sialidases; translocation; binary clostridial actin ADP-ribosylating toxins; dendrimers; clostridial toxins; food-poisoning; anti-toxins; intestinal pathogenesis; pharmacological inhibitors; membrane transport; probiotic microorganisms
• Online Access: DOAB: download the publication; DOAB: description of the publication

Many medically relevant bacteria cause severe human and animal diseases because they produce and release protein toxins that target mammalian cells. Because the toxin-induced cell damage is the reason for the clinical symptoms, the targeted pharmacological inhibition of the cytotoxic mode of action...