On the Origin and Function of Human NK-like CD8+ T Cells: Charting New Territories

• Main Author: Fernando A. Arosa (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2018
• Series: Frontiers Research Topics
• Subjects: Medicine; Open conformers; Disease control; Adaptive; Innate receptors; Successful aging; Regulatory; Suppressor; Tissue repair; Cytotoxic; MHC class I
• Online Access: DOAB: download the publication; DOAB: description of the publication

Human CD8+ T cells expressing NK receptors and receptors found on innate immune cells, and designated as NK-like or innate CD8+ T cells, have been long considered as terminally differentiated lymphocytes responsible for tissue inflammation and destruction. However, a growing body of knowledge is unv...