The Origin of the Plasma Cell Heterogeneity

• Главный автор: Thierry Defrance (auth)
• Другие авторы: Catherine Pellat-Deceunynck (auth)
• Формат: Электронный ресурс Глава книги
• Язык: английский
• Опубликовано: Frontiers Media SA 2015
• Серии: Frontiers Research Topics
• Предметы: Medicine; IL21; Autoimmunity; differentiation; Cell Cycle; B-cell; Plasma cell; Myeloma; Autophagy; B1
• Online-ссылка: DOAB: download the publication; DOAB: description of the publication

Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controve...