The Origin of the Plasma Cell Heterogeneity

• Main Author: Thierry Defrance (auth)
• Other Authors: Catherine Pellat-Deceunynck (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; IL21; Autoimmunity; differentiation; Cell Cycle; B-cell; Plasma cell; Myeloma; Autophagy; B1
• Online Access: DOAB: download the publication; DOAB: description of the publication

Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controve...