The Origin of the Plasma Cell Heterogeneity

• Autore principale: Thierry Defrance (auth)
• Altri autori: Catherine Pellat-Deceunynck (auth)
• Natura: Elettronico Capitolo di libro
• Lingua: inglese
• Pubblicazione: Frontiers Media SA 2015
• Serie: Frontiers Research Topics
• Soggetti: Medicine; IL21; Autoimmunity; differentiation; Cell Cycle; B-cell; Plasma cell; Myeloma; Autophagy; B1
• Accesso online: DOAB: download the publication; DOAB: description of the publication

Riassunto

Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controversial whether the regulation of PCs numbers and the "active" in vivo Ig diversity depend or not on non-specific reactivation of B-cells during infections. Depending on the stimulus (T-independent/T-dependent antigen, cytokines, partner cells) and B-cell types (naïve or memory, circulating or germinal center, lymph nodes or spleen, B1 or B2...), both the phenotype and isotype of PCs differ suggesting that PC diversity is either linked to B-cell diversity or to the type of stimulus or to both. Knowledge of the mechanisms supporting PC diversity has important consequences for the management of i) plasma cell neoplasia such as Multiple Myeloma and Waldenström's Macroglobulinemia, ii) vaccine protection against pathogens and iii) auto-immune diseases.

Descrizione fisica

1 electronic resource (80 p.)

ISBN

978-2-88919-734-7
9782889197347

Accesso

Open Access