The Origin of the Plasma Cell Heterogeneity

• Hoofdauteur: Thierry Defrance (auth)
• Andere auteurs: Catherine Pellat-Deceunynck (auth)
• Formaat: Elektronisch Hoofdstuk
• Taal: Engels
• Gepubliceerd in: Frontiers Media SA 2015
• Reeks: Frontiers Research Topics
• Onderwerpen: Medicine; IL21; Autoimmunity; differentiation; Cell Cycle; B-cell; Plasma cell; Myeloma; Autophagy; B1
• Online toegang: DOAB: download the publication; DOAB: description of the publication

Plasma cells (PCs) are terminally differentiated B-cells producing large amounts of immunoglobulins (Ig). In humans, most of circulating Ig are produced by bone marrow plasma cells. PCs differentiate from activated naïve or memory B-cells usually activated by specific antigens. It is still controve...