Parkinson's Disease Cell Vulnerability and Disease Progression

• Main Author: Jose A. Obeso (auth)
• Other Authors: Javier Blesa (auth), Jose L. Lanciego (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Neurosciences; Striatum; synuclein; Mitochondria; Cell vulnerability; Dopamine; Substantia Nigra; Dopaminergic Neurons; Parkinson's Disease; habitual behavior
• Online Access: DOAB: download the publication; DOAB: description of the publication

Parkinson's disease is a neurodegenerative disorder that affects 1.5% of the global population over 65 years of age. The hallmark feature of this disease is the degeneration of dopamine neurons in the substantia nigra pars compacta and a consequent striatal dopamine deficiency. The pathogenesis...