Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach

• Auteur principal: Paolo Bonaldo (auth)
• Autres auteurs: Luciano Merlini (auth), Emanuele Marzetti (auth)
• Format: Électronique Chapitre de livre
• Langue: anglais
• Publié: Frontiers Media SA 2015
• Collection: Frontiers Research Topics
• Sujets: Neurosciences; Aging sarcopenia; muscular dystrophy; Mitochondrial dysfunction; therapy; skeletal muscle; Autophagy; Animal Models; Apoptosis; satellite cells; muscle imaging
• Accès en ligne: DOAB: download the publication; DOAB: description of the publication

Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autop...