Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach

• Main Author: Paolo Bonaldo (auth)
• Other Authors: Luciano Merlini (auth), Emanuele Marzetti (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Neurosciences; Aging sarcopenia; muscular dystrophy; Mitochondrial dysfunction; therapy; skeletal muscle; Autophagy; Animal Models; Apoptosis; satellite cells; muscle imaging
• Online Access: DOAB: download the publication; DOAB: description of the publication

Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autop...