Pathophysiological Mechanisms of Sarcopenia in Aging and in Muscular Dystrophy: A Translational Approach

Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autop...

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Bibliographic Details
Main Author: Paolo Bonaldo (auth)
Other Authors: Luciano Merlini (auth), Emanuele Marzetti (auth)
Format: Electronic Book Chapter
Language:English
Published: Frontiers Media SA 2015
Series:Frontiers Research Topics
Subjects:
Online Access:DOAB: download the publication
DOAB: description of the publication
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520 |a Loss of muscle mass and increased fibrosis characterize both sarcopenia of aging and muscular dystrophy. Research is increasingly showing that these two conditions also share several pathophysiological mechanisms, including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and abnormal regulation of signaling and stress response pathways. This Research Topic will cover several mechanisms involved in aging and dystrophic sarcopenia and explore the therapeutic potential of various strategies for intervention. 
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653 |a Aging sarcopenia 
653 |a muscular dystrophy 
653 |a Mitochondrial dysfunction 
653 |a therapy 
653 |a skeletal muscle 
653 |a Autophagy 
653 |a Animal Models 
653 |a Apoptosis 
653 |a satellite cells 
653 |a muscle imaging 
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