The Physiology and Pharmacology of Leucine-rich Repeat GPCRs

• Main Author: Brian J. Arey (auth)
• Other Authors: James A. Dias (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2016
• Series: Frontiers Research Topics
• Subjects: Medicine; Leucine- rich repeat; TSH; GPCR; R-spondin; FSH; Pharmacology; LH; Relaxin; LRR
• Online Access: DOAB: download the publication; DOAB: description of the publication

G protein-coupled receptors (GPCRs) represent a large and physiologically important class of cell surface receptors. There are approximately 750 known GPCRs present in the human genome that can be subdivided into general classes based upon sequence homology within their transmembrane domains. Therap...