PI3K signalling

• Main Author: Martin Turner (auth)
• Other Authors: Klaus Okkenhaug (auth), Michael R. Gold (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2015
• Series: Frontiers Research Topics
• Subjects: Medicine; B cell; PI3K/AKT/mTOR; Signal Transduction; T cell; PI3K pathway inhibitors
• Online Access: DOAB: download the publication; DOAB: description of the publication

The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the r...