PI3K signalling

• Κύριος συγγραφέας: Martin Turner (auth)
• Άλλοι συγγραφείς: Klaus Okkenhaug (auth), Michael R. Gold (auth)
• Μορφή: Ηλεκτρονική πηγή Κεφάλαιο βιβλίου
• Γλώσσα: Αγγλικά
• Έκδοση: Frontiers Media SA 2015
• Σειρά: Frontiers Research Topics
• Θέματα: Medicine; B cell; PI3K/AKT/mTOR; Signal Transduction; T cell; PI3K pathway inhibitors
• Διαθέσιμο Online: DOAB: download the publication; DOAB: description of the publication

The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the r...