PI3K signalling

The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the r...

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Bibliographic Details
Main Author: Martin Turner (auth)
Other Authors: Klaus Okkenhaug (auth), Michael R. Gold (auth)
Format: Electronic Book Chapter
Language:English
Published: Frontiers Media SA 2015
Series:Frontiers Research Topics
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Online Access:DOAB: download the publication
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