Polyamine Metabolism in Disease and Polyamine-Targeted Therapies

• Main Author: Murray-Stewart, Tracy (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2019
• Subjects: Biology, life sciences; protein synthesis in cancer; neuroblastoma; epigenetics; Drosophila imaginal discs; pneumococcal pneumonia; transgenic mice; spermidine/spermine N1-acetyl transferase; ?-difluoromethylornithine; MYC; skeletal muscle; protein expression; curcumin; colorectal cancer; autophagy; human embryonic kidney 293 (HEK293); melanoma; tumor immunity; Snyder-Robinson Syndrome; Streptococcus pneumoniae; B-lymphocytes; autoimmunity; spermine oxidase; cell differentiation; diferuloylmethane; immunity; antizyme; transgenic mouse; polyamine; hirsutism; chemoprevention; CRISPR; transglutaminase; polyamine analogs; NF-?B; spermine synthase; atrophy; aging; oxidative stress; mast cells; African sleeping sickness; pancreatic ductal adenocarcinoma; eflornithine; carcinogenesis; ornithine decarboxylase; polyamine transport inhibitor; putrescine; neutrophils; spermidine; untranslated region; spermine; polyphenol; M2 macrophages; polyamine transport system; metabolism; difluoromethylorthinine; DFMO; antizyme inhibitors; capsule; polyamine transport; eosinophils; MCF-7 cells; difluoromethylornithine; polyamine metabolism; mutant BRAF; polyamines; cadaverine; proteomics; airway smooth muscle cells; breast cancer; X-linked intellectual disability; complementation; T-lymphocytes; bis(ethyl)polyamine analogs; antizyme 1; cancer; osteosarcoma
• Online Access: DOAB: download the publication; DOAB: description of the publication

Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with...