Preclinical and clinical issues in Alzheimer's disease drug research and development

• मुख्य लेखक: Silvana Gaetani (auth)
• अन्य लेखक: Cesare Mancuso (auth)
• स्वरूप: इलेक्ट्रोनिक पुस्तक अध्याय
• भाषा: अंग्रेज़ी
• प्रकाशित: Frontiers Media SA 2015
• श्रृंखला: Frontiers Research Topics
• विषय: Pharmacology; preclinical studies; neurodegeneration; Clinical Trials as Topic; drug research and development; Alzheimer's disease
• ऑनलाइन पहुंच: DOAB: download the publication; DOAB: description of the publication

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called "amyloid cascade hypothesis", amyloid-ß- peptide (Aß)...