Preclinical and clinical issues in Alzheimer's disease drug research and development

• Hoofdauteur: Silvana Gaetani (auth)
• Andere auteurs: Cesare Mancuso (auth)
• Formaat: Elektronisch Hoofdstuk
• Taal: Engels
• Gepubliceerd in: Frontiers Media SA 2015
• Reeks: Frontiers Research Topics
• Onderwerpen: Pharmacology; preclinical studies; neurodegeneration; Clinical Trials as Topic; drug research and development; Alzheimer's disease
• Online toegang: DOAB: download the publication; DOAB: description of the publication

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called "amyloid cascade hypothesis", amyloid-ß- peptide (Aß)...