Preclinical and clinical issues in Alzheimer's disease drug research and development

• Главный автор: Silvana Gaetani (auth)
• Другие авторы: Cesare Mancuso (auth)
• Формат: Электронный ресурс Глава книги
• Язык: английский
• Опубликовано: Frontiers Media SA 2015
• Серии: Frontiers Research Topics
• Предметы: Pharmacology; preclinical studies; neurodegeneration; Clinical Trials as Topic; drug research and development; Alzheimer's disease
• Online-ссылка: DOAB: download the publication; DOAB: description of the publication

Alzheimer's disease (AD) is a chronic neurodegenerative disorder characterized by progressive cognitive dysfunction and memory loss, inability to perform the activities of daily living and mood disorders. According to the so-called "amyloid cascade hypothesis", amyloid-ß- peptide (Aß)...