Reelin-Related Neurological Disorders and Animal Models

• Main Author: Laura Lossi (auth)
• Other Authors: Adalberto Merighi (auth), Gabriella D'Arcangelo (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2017
• Series: Frontiers Research Topics
• Subjects: Neurosciences; Neurons; neuronal migration; Schizophrenia; Depression; Neuronal Death; Reeler; Synapses; autism; intracellular pathways
• Online Access: DOAB: download the publication; DOAB: description of the publication

The Reeler mutation was so named because of the alterations in gait that characterize homozygous mice. Several decades after the description of the Reeler phenotype, the mutated protein was discovered and named Reelin (Reln). Reln controls a number of fundamental steps in embryonic and postnatal bra...