The Role of AAA+ Proteins in Protein Repair and Degradation

• Main Author: James Shorter (auth)
• Other Authors: Walid A. Houry (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2018
• Series: Frontiers Research Topics
• Subjects: ATPases Associated with diverse cellular Activities; Hsp104; Torsin; Pontin; Lon; Rubisco activase; ClpXP; Reptin; p97; Proteasome
• Online Access: DOAB: download the publication; DOAB: description of the publication

ATPases Associated with diverse cellular Activities (AAA+) comprise a superfamily of proteins that are defined by the presence of the AAA+ domain containing canonical Walker A and B motifs required for ATP binding and hydrolysis. Members of this superfamily act on other proteins, DNA, RNA, or multic...