Role of DNA Methyltransferases in the Epigenome

• Main Author: Jeltsch, Albert (auth)
• Other Authors: Gowher, Humaira (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Biology, life sciences; DNMTs; n/a; histone modification; TBRS; DNA methyltransferases; autoinhibition; epigenetics; DNMT; cell identity; embryogenesis; dwarfism; DNMT3B; germ cells; HSAN1E; USP7; DNMT3A; DNA methyltransferase; gene expression; DNMT1; de novo DNA methylation; DNA methyltransferase structure; UHRF1; DNA methyltransferase mechanism; allosteric regulation; rare diseases; DNA Methylation; maintenance DNA methylation; DNA methylation; ADCA-DN; PCC/PGL; ubiquitination; TETs; DNA methyltransferase function; molecular epigenetics; DNA methyltransferase regulation
• Online Access: DOAB: download the publication; DOAB: description of the publication

DNA methylation, a modification found in most species, regulates chromatin functions in conjunction with other epigenome modifications, such as histone post-translational modifications and non-coding RNAs. In mammals, DNA methylation has an essential role in development by orchestrating the generati...