Roles and Functions of ROS and RNS in Cellular Physiology and Pathology

• Main Author: Zarkovic, Neven (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: MDPI - Multidisciplinary Digital Publishing Institute 2020
• Subjects: Medicine; toxicity; toll-like receptors; acrolein; hydroxyapatite-based biomaterials; LC-MS/MS; blood-brain barrier; NADPH-oxidase; human neuroblastoma SH-SY5Y cells; NRF2-NQO1 axis; granulocytes; free radicals; antioxidant; plaque vulnerability; bEnd.3; relaxation; Ca2+; keratinocytes; oxidative metabolism of the cells; lipid peroxidation; intermittent hypoxia; osteoblast growth; UV radiation; ROS; bEnd5; cyclopurines; NF?B; glucose deprivation; antimicrobial; endothelial cells; 4-hydroxynonenal (4-HNE); histamine; glutamine deprivation; optical coherence tomography; antioxidants; DNA damage; glutathione; NQO1 transcript variants; xeroderma pigmentosum; cancer cells; VAS2870; reactive oxygen species (ROS); TP53 mutation; DNA and RNA polymerases; viability; oxidative burst; macrophages; inflammation; Nrf2; von Willebrand factor; reactive oxygen species; growth control; intracellular signaling; MFN2; nuclear factor erythroid 2-related factor 2; fusion/fission; IMR-90; calcium; proliferation; mitochondria; pathophysiology of oxidative stress; redox balance; 4-hydroxynonenal; cannabidiol; oxidative homeostasis; rs1800566; neuronal cell death; heme-oxygenase-1; vitamins; cell signaling; TRPM2 channel; aorta; cancer; growth; cancer regression; oxidative stress; nucleotide excision repair
• Online Access: DOAB: download the publication; DOAB: description of the publication

Our common knowledge on oxidative stress has evolved substantially over the years and has been mostly focused on the fundamental chemical reactions and the most relevant chemical species involved in the human pathophysiology of oxidative stress-associated diseases. Thus, reactive oxygen species and...