Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond

• मुख्य लेखक: Stefano Morotti (auth)
• अन्य लेखक: Eleonora Grandi (auth), Esther Pueyo (auth), Blanca Rodriguez (auth)
• स्वरूप: इलेक्ट्रोनिक पुस्तक अध्याय
• भाषा: अंग्रेज़ी
• प्रकाशित: Frontiers Media SA 2018
• श्रृंखला: Frontiers Research Topics
• विषय: Physiology; cardiotoxicity; cardiac electrophysiology.; drug-induced arrhythmia; QT interval prolongation; multi-scale modeling
• ऑनलाइन पहुंच: DOAB: download the publication; DOAB: description of the publication

Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of...