Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond

• Main Author: Stefano Morotti (auth)
• Other Authors: Eleonora Grandi (auth), Esther Pueyo (auth), Blanca Rodriguez (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2018
• Series: Frontiers Research Topics
• Subjects: Physiology; cardiotoxicity; cardiac electrophysiology.; drug-induced arrhythmia; QT interval prolongation; multi-scale modeling
• Online Access: DOAB: download the publication; DOAB: description of the publication

Summary

Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of articles presenting new technological and conceptual advances, including refinement of ex vivo and in vitro assays, screens and models, and in silico approaches reflecting the increasing effort that has been put forward by regulatory agencies, industry, and academia to try and address the need of a more accurate, mechanistically-based paradigm of proarrhythmic potential of drugs. This Research Topic is dedicated to the memory of Dr. J. Jeremy Rice, our wonderful friend and colleague.

Physical Description

1 electronic resource (385 p.)

ISBN

978-2-88945-539-3
9782889455393

Access

Open Access