Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond

Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of...

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Bibliographic Details
Main Author: Stefano Morotti (auth)
Other Authors: Eleonora Grandi (auth), Esther Pueyo (auth), Blanca Rodriguez (auth)
Format: Electronic Book Chapter
Language:English
Published: Frontiers Media SA 2018
Series:Frontiers Research Topics
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Summary:Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of articles presenting new technological and conceptual advances, including refinement of ex vivo and in vitro assays, screens and models, and in silico approaches reflecting the increasing effort that has been put forward by regulatory agencies, industry, and academia to try and address the need of a more accurate, mechanistically-based paradigm of proarrhythmic potential of drugs. This Research Topic is dedicated to the memory of Dr. J. Jeremy Rice, our wonderful friend and colleague.
Physical Description:1 electronic resource (385 p.)
ISBN:978-2-88945-539-3
9782889455393
Access:Open Access