Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond

• Main Author: Stefano Morotti (auth)
• Other Authors: Eleonora Grandi (auth), Esther Pueyo (auth), Blanca Rodriguez (auth)
• Format: Electronic Book Chapter
• Language: English
• Published: Frontiers Media SA 2018
• Series: Frontiers Research Topics
• Subjects: Physiology; cardiotoxicity; cardiac electrophysiology.; drug-induced arrhythmia; QT interval prolongation; multi-scale modeling
• Online Access: DOAB: download the publication; DOAB: description of the publication

Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of...