T Cell Regulation by the Environment

• Päätekijä: Anne L. Astier (auth)
• Muut tekijät: David A. Hafler (auth)
• Aineistotyyppi: Elektroninen Kirjan osa
• Kieli: englanti
• Julkaistu: Frontiers Media SA 2015
• Sarja: Frontiers Research Topics
• Aiheet: Medicine; regulatory T cells; Vitamin D; helminth; T cells; Metabolism; microbiome
• Linkit: DOAB: download the publication; DOAB: description of the publication

Yhteenveto

Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation. Parasite infection can also skew Th differentiation. Similarly, the gut microbiota regulates the development of immune responses. Lastly, the key role of metabolism on T cells has also been demonstrated. This series of articles highlights some of the multiple links existing between environmental factors and T cell responses.

Ulkoasu

1 electronic resource (115 p.)

ISBN

978-2-88919-733-0
9782889197330

Pääsy

Open Access