T Cell Regulation by the Environment
Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset d...
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| Format: | Électronique Chapitre de livre |
| Langue: | anglais |
| Publié: |
Frontiers Media SA
2015
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| Collection: | Frontiers Research Topics
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| Accès en ligne: | DOAB: download the publication DOAB: description of the publication |
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| Résumé: | Naïve T cells get activated upon encounter with their cognate antigen and differentiate into a specific subset of effector cells. These T cells are themselves plastic and are able to re-differentiate into another subset, changing both phenotype and function. Differentiation into a specific subset depends on the nature of the antigen and of the environmental milieu. Notably, certain nutrients, such as vitamins A and D, sodium chloride, have been shown to modulate T cell responses and influence T cell differentiation. Parasite infection can also skew Th differentiation. Similarly, the gut microbiota regulates the development of immune responses. Lastly, the key role of metabolism on T cells has also been demonstrated. This series of articles highlights some of the multiple links existing between environmental factors and T cell responses. |
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| Description matérielle: | 1 electronic resource (115 p.) |
| ISBN: | 978-2-88919-733-0 9782889197330 |
| Accès: | Open Access |